Comparative Metabolism of Radionuclides in Mammals - VII. Retention of 106Ru in the Mouse, Rat, Monkey and Dog

Abstract

Whole-body retention of 106RuCl3 as a function of time was measured in mice, rats, monkeys, and dogs. Retention after oral dosage and after parenteral injection was measured in the four species. About 4% of an oral dose is absorbed in the gastrointestinal tract, and about 20% of a parenteral dose is lost with an effective halftime of about 200 days. The highest concentrations were found in the kidney, while bone maintained about 6% of the body burden over a period of 8 months. Such values are compared with values in the literature. Estimates of the maximum permissible concentration in water were greater for the target organs examined than the limiting value of 10−4 μCi/cm3 set by the ICRP for the lower large intestine.