Proceedings of the National Academy of Sciences · 1981 · 315 citations · 16 references
Life SciencesBiophysicsNeuroscienceElectrophysiologyMembrane BiophysicsNeurophysiologyIon Channel PhysiologyIon ChannelsNeuronal Membrane PropertiesNeurotransmitter ReleaseSynaptic TransmissionSynaptic Vesicle ReleaseCalcium Channel ConductanceCalcium Channel FunctionCalcium Channel PhysiologyCalcium Signaling In SynapsesCalcium TransportPresynaptic Calcium ChannelsSynaptic CurrentsVoltage-gated Calcium Channels
The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0.21 pS, compares favorably with conductances of calcium channels in other preparations, substantiating the idea that the large intramembrane particles, which are concentrated at "active zones," represent calcium channels.
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Single-channel currents recorded from membrane of denervated frog muscle fibres
Erwin Neher, Bert Sakmann · Nature · 1976 · 2.5K citations