Clinical studies of viruses as antineoplastic agents, with particular reference to egypt 101 virus

Abstract

HIS PAPER presents the experimental clin-T ical evidence, to date, that indicates that certain viruses have the capacity in man, as in experimental animals, to localize in and damage some neoplastic tissues.Only such data as are pertinent to this objective are presented here.Detailed data on virology, serology, and clinical course of these induced virus infections will be reported elsewhere. LABORAKIRY BACKGROUNDCertain viruses inhibit the growth of certain transplanted tumors in mice.?, 47 57 7, 10, 13918 Relatively few of the many viruses tested have this capacity.When tumor inhibition occurs, virus is invariably present in the tumor.Tumor inhibition never occurs if virus fails to inultiply.These observations suggest that the virus particle itself, rather than host reaction, causes the antitumor effect.Further evidence for this is seen in the fact that the tumor-restraining capacity of a virus can, by adaptation, be enhanced without change in the effect of the virus on normal tissues of the host.6I n most of the laboratory studies on this phenomenon, virus-susceptible mice have been used, and consequently thc virus infection itself has been almost invariably fatal.Studies with fowl-bearing KPL-12 lymphomatosis,'2