Bioscience Biotechnology and Biochemistry · 1996 · 84 citations · 0 references
Life SciencesMicrobiologyPharmacologyMedical MicrobiologyMolecular VirologyVirologyAntibacterial PharmacologyAntibiotic FermentationAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyViral MaturationAntiviral Drug MechanismsAntiviral Mechanisms Of ActionAntiviral TherapeuticsDna Replication InhibitorsMacrolide Antibiotics
The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.