Publication | Closed Access
P(RNCH<sub>2</sub>CH<sub>2</sub>)<sub>3</sub>N-Catalyzed Synthesis of β-Hydroxy Nitriles
92
Citations
20
References
1999
Year
β-Hydroxy NitrilesEngineeringSuccessful SynthesisOrganic ChemistryCatalysisBeta-hydroxy NitrilesChemistryMagnesium SaltsAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisCatalytic SynthesisNatural Product Synthesis
We herein report the successful synthesis of beta-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced.
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