Disruption of Rac1 signaling reduces ischemia–reperfusion injury in the diabetic heart by inhibiting calpain

Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections

Hilary King, Ronald E. Aubert, William H. Herman · Diabetes Care · 1998 · 6.3K citations

Public Health, Demography, Population Health Sciences +14

Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study

Mariano J Garcia, Patricia McNamara, Tavia Gordon et al. · Diabetes · 1974 · 1.6K citations

Medicine, Cardiology, Endocrinology +17

Diabetes Patients Requiring Glucose-Lowering Therapy and Nondiabetics With a Prior Myocardial Infarction Carry the Same Cardiovascular Risk

Tina Ken Schramm, Gunnar Gislason, Lars Køber et al. · Circulation · 2008 · 541 citations

Medicine, Cardiology, Internal Medicine +12

Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment

Christoph Maack, Tanja Kartes, Heiko Kilter et al. · Circulation · 2003 · 419 citations · Full text

Life Sciences, Cardiology, Pharmacology +16

Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion

Min Chen, Huaping He, Shixing Zhan et al. · Journal of Biological Chemistry · 2001 · 387 citations · Full text

Life Sciences, Biochemistry, Cell Biology +15