Uptake and Metabolism<i>in Vivo</i>of Testosterone-1,2-³H by Accessory Sex Organs of Male Rats; Influence of Some Hormonal Compounds

Abstract

A study was made of the influence of certain hormones and synthetic hormonal compounds on the uptake of radioactivity by rat seminal vesicles and prostate gland following the administration of testosterone-l,2-3H in vivo. Androstenedione, 17β-methyltestosterone, 17βmethyl-β-nortestosterone (SK & F 7690), progesterone and corticosterone reduced the uptake of radioactivity. 17β-Estradiol and diethylstilbestrol did not reduce the uptake; indeed, in the lateral prostate an increased accumulation of radioactivity was observed. One hr after administration of testosterone-3H, unchanged testosterone represented 3.0–17.1& of the total radioactivity in the accessory sex organs. 5a- Androstan-17β-ol-3-one was the main metabolite, constituting about 70% of the total radioactivity. (Endocrinology85: 683, 1969)