SYSTEMIC ADMINISTRATION OF PHOSPHODIESTERASE V INHIBITOR, SILDENAFIL CITRATE, FOR ATTENUATION OF CEREBRAL VASOSPASM AFTER EXPERIMENTAL SUBARACHNOID HEMORRHAGE

Abstract

The vasodilatory effect of SC was observed to be significant on normal cerebral vessels and after SAH-induced vasospasm. SC did not prevent apoptosis of the endothelium in our study, which suggests that prevention of apoptosis is not necessary in the treatment of cerebral vasospasm.