Low Accumulation of L90M in Protease from Subtype F HIV‐1 with Resistance to Protease Inhibitors Is Caused by the L89M Polymorphism

Abstract

The L89M mutation in subtype F viruses is a high genetic barrier to the accumulation of the L90M resistance mutation and can function as a resistance mutation, depending on the presence of other polymorphisms in the subtype F PR backbone.