Can Determining the Minimum Alveolar Anesthetic Concentration of Volatile Anesthetic Be Used as an Objective Tool to Assess Antinociception in Animals?

Abstract

The MAC-sparing effect provides several variables that allow comparison between different analgesic substances. However, the observations made are not simply the result of the antinociceptive effects of the tested drugs but rather the result of complex interactions between these drugs and a halogenated vapor.