Radiodiagnosis of peptic ulcer with technetium-99m-pantoprazole

Abstract

Pantoprazole, antiulcer drug, was labeled with 99m Tc to obtain an agent for ulcer imaging. The radiochemical yield of 99m Tc-Pantoprazole reaches approximately 96.5%. The optimum conditions are as follows: pH 10, 75 μg of tin chloride, 30 min, and 2 mg of the substrate. 99m Tc-Pantoprazole was stable for 3 h. Intravenous biodistribution studies of 99m Tc-Pantoprazole revealed high concentration in the stomach ulcer, reaching about 27.2% of the total injected dose at 30 min post injection. This concentration of 99m Tc-Pantoprazole in stomach ulcer makes this agent promising for stomach ulcer imaging.