Archiv der Pharmazie · 1999 · 113 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryAnalgesic PharmacologyGastrointestinal PharmacologyStructure-activity Relationship AnalysisAcute Drug ToxicityAcute Tissue Toxicity
Several new 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.