Publication | Closed Access
Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives
113
Citations
0
References
1999
Year
Ulcerogenic EffectMedicinal ChemistryPharmaceutical ScienceBioorganic ChemistryDerivative (Chemistry)BiochemistryAntiparasitic AgentMedicineNatural SciencesPharmacological ActivitiesPharmacological AgentOrganic ChemistryPharmacotherapyAcute ToxicityPharmacology-One DerivativesPharmaceutical ChemistryDrug Discovery
Several new 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.