THE RELATIVE IMPORTANCE OF ANDROGEN AND ESTROGEN IN THE SELECTIVE UPTAKE OF ZN⁶⁵BY THE DORSOLATERAL PROSTATE OF THE RAT

Abstract

THE striking ability of the dorsolateral prostate of the mature rat to concentrate administered Zn65 (Gunn, Gould et al., 1955) led to a study of the endocrine factors possibly controlling the selective uptake of Zn65 by this accessory sex gland. The uptake of Zn65 by the dorsolateral prostate was studied in male Wistar rats of various age groups and in various states of induced hormonal imbalance. The hormones were administered for six days prior to the initiation of the Zn65 studies. All experiments were done between the months of July and October, and control animals were run with each experiment.