Brain uptake of ketoprofen–lysine prodrug in rats

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

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Engineering, Computational Chemistry, Polar Fragments +19

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

Peter Teismann, Kim Tieu, Dong‐Kug Choi et al. · Proceedings of the National Academy of Sciences · 2003 · 656 citations · Full text

Mitophagy, Neurodegenerative Diseases, Cox-2 Inhibition +13

Selective expression of the large neutral amino acid transporter at the blood–brain barrier

Rubén J. Boado, Jian Yi Li, Marie Nagaya et al. · Proceedings of the National Academy of Sciences · 1999 · 472 citations

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

J. Cory Kalvass, Tristan S. Maurer · Biopharmaceutics & Drug Disposition · 2002 · 413 citations

Transport of Amino Acid-Related Compounds Mediated by L-Type Amino Acid Transporter 1 (LAT1): Insights Into the Mechanisms of Substrate Recognition

Hiroshi Uchino, Yoshikatsu Kanai, Do Kyung Kim et al. · Molecular Pharmacology · 2002 · 404 citations

Protein Chemistry, Amino Acid-related Compounds, Biochemistry +8