Biological and Mechanistic Activities of Phenazine Antibiotics Produced by Culture LL-14I352.

Abstract

In the course of screening microorganisms isolated fromthe marineenvironment,fermentation samplesof culture LL-141352 were found to exhibit activity in the Biochemical Induction Assay (BIA), which detects agents that directly or indirectly initiate DNAdamage1}. This culture was originally isolated from an orange tunicate collected from the Pacific Ocean in proximity to Fiji and was subsequently identified as a new halophilic marine bacterium2). The BIA-active compounds isolated from fermentations of this culture were found to be the new phenazine antibiotics LL-14I352a and /?, which also