Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody‐induced inflammation in Fcγ receptor IIa–transgenic mice

Abstract

The presence of enhanced passive and induced autoimmunity, as well as the emergence of spontaneous autoimmune disease at 20-45 weeks of age, suggest that FcgammaRIIa is a very important factor in the pathogenesis of autoimmune inflammation and a possible target for therapeutic intervention.