Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Richard Palmer, Anthony G. Ferrige, Salvador Moncada · Nature · 1987 · 10.8K citations

Veterinary Medicine, Cell Biology, Physiology +10

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

L J Ignarro, Howard Lippton, Jo C. W. Edwards et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 1.6K citations

Life Sciences, Biophysics, Physiology +6

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

Robert M. Rapoport, Ferid Murad · Circulation Research · 1983 · 933 citations · Full text

Medicine, Pharmacology, Physiology +12

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

Carl A. Gruetter, Darlene Y. Gruetter, Jessica Lyon et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 534 citations

Life Sciences, Pharmacology, Physiology +13

Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates.

Paul Freiman, Grant Mitchell, Donald D. Heistad et al. · Circulation Research · 1986 · 407 citations · Full text

Life Sciences, Pharmacology, Physiology +15