Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3

Abstract

In light of the recent studies suggesting that genetic variants near TIMP-3 influence susceptibility to age-related macular degeneration, these results imply that TIMP-3 may regulate the development of the choroidal vasculature and is a likely contributor to increased susceptibility to choroidal neovascularization.