Multicomponent Syntheses based upon Copper‐Catalyzed Alkyne‐Azide Cycloaddition

Abstract

Abstract The copper‐catalyzed alkyne‐azide cycloaddition (CuAAC) is a highly versatile, regioselective synthesis of 1,4‐disubstituted 1,2,3‐triazoles under mild reaction conditions and has found numerous applications in medicinal, bioorganic, and materials chemistry in the past one and a half decades. By virtue of the enormous tolerance for functional groups and the mild reaction conditions, CuAAC has become increasingly important in combination with multicomponent reactions (MCR), either in a domino or in a consecutive fashion. While the majority of CuAAC‐based MCR are founded on the in situ or en route generation of azides, one‐pot generation of alkynes and the concatenation with other MCR are rapidly catching up and novel sequences for efficient one‐pot syntheses of triazole‐based structures in a multicomponent fashion are constantly evolving. This review summarizes important contributions of CuAAC‐based MCR including MCR‐type applications in polymer science. magnified image