Enantioselective Transfer Hydrogenation of Difluoromethyl Ketimines Using Benzothiazoline as a Hydrogen Donor in Combination with a Chiral Phosphoric Acid

Abstract

Hold the benzothiazoline: Highly enantioselective transfer hydrogenation of difluoromethyl ketimines with benzothiazolines catalyzed by a chiral phosphoric acid furnishes α-difluoromethylated amines in good yields and with excellent enantioselectivity, irrespective of the stereochemistry of the starting materials. PMP=p-methoxyphenyl. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.