1-<i>O</i>-Palmityl-D-glucuronate Endows Liposomes with Long Half-Life In Vivo

Abstract

Abstract More liposomes containing 1-O-palmityl-D-glucuronic acid (PGA), a synthetic glycolipid, bound to macrophages than those containing phosphatidylglycerol did in vitro; however, PGA-liposomes circulated longer in vivo. PGA-liposomes did not aggregate in the presence of serum, but liposomes containing 1-O-palmityl-D-glucose or myristic acid aggregated rapidly, suggesting that both carbohydrate and carboxyl group of PGA are important for preventing liposomal aggregation in serum. This low agglutinative character may be one of the factors for long circulation of PGA-liposomes in vivo.