A Prospective, Randomized, Blinded, and Placebo-Controlled Trial of Intraoperative Intra-arterial Urokinase Infusion During Lower Extremity Revascularization

Abstract

Intraoperative bolus UK infusion is safe, with no significant fibrinogen depletion or increased operative blood loss or wound hematoma formation. Dose-related plasminogen activation resulted in significant breakdown in cross-linked fibrin in the distal circulation. Intraoperative bolus UK infusion may be valuable as an adjunct in patients with chronic occlusive disease who are undergoing revascularization. Detailed randomized studies are indicated to establish clinical efficacy.