Synthesis of Functionalized 2‐Aminopyrroles by Lewis Acid Catalyzed Ring‐opening of 1,1,2,3‐Tetrasubstituted Cyclopropanes with Arylamines

Ying Han, Qin Fu, Wan‐Quan Tang, Chao‐Guo Yan

Chinese Journal of Chemistry · 2012 · 15 citations · 25 references

Concepts

Abstract

Abstract Under the catalysis of Lewis acid Co(ClO 4 ) 2 the reaction of the sterically hindered 1,1,2,3‐tetrasubstituted cyclopropanes with arylamines in refluxing THF gave the functionalized 2‐aminopyrroles with sequential ring‐opening of cyclopropane, nucleophilic substitution, nucleophilic addition of cyano group and recyclization processes.

References

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