Immature Syngeneic Dendritic Cells Potentiate Tolerance to Pancreatic Islet Allografts Depleted of Donor Dendritic Cells in Microgravity Culture Condition

Abstract

Allogeneic islets depleted of donor DCs by culture in bioreactors have almost twofold better acceptance in Balb/c(stat4 -/-) than in Balb/c(stat6 -/-) mice, but lack Treg cells. Additional injection of host immature DCs improves tolerance in Balb/c and Balb/c(stat4 -/-) recipients by inducing potent CD4+ CD25+ Treg cells.