A General and Efficient Suzuki–Miyaura Cross‐Coupling Protocol Using Weak Base and No Water: The Essential Role of Acetate

Abstract

Abstract A weak base, CsOAc, promotes Suzuki–Miyaura cross‐coupling and related Pd‐catalyzed reactions under anhydrous conditions as effectively as stronger bases. Aryl triflates exhibit unusual reaction rates, which are comparable to that of bromoarenes. A neglected six‐membered transition‐state model was proposed to give alternative insight into the key process of transmetalation.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)