The Effect of α-2 Adrenergic Agonists on Memory and Cognitive Flexibility

Abstract

Therefore, alpha2-agonists do not influence cognitive flexibility in the same manner as beta-antagonists. Better performance on memory with clonidine might be expected based on primate studies demonstrating benefits in working memory using clonidine. This benefit was not observed for the commonly used clinical memory tasks in our study. This may have implications for why clonidine has not demonstrated efficacy for cognitive disorders such as Alzheimer disease, despite its known benefit for working memory in animal models.