Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp³)–H bonds with aryl halides

Abstract

In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp(3))-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp(3))-H bond arylation.