Perhaloalkylation of Metal Enolates—Unconventional and Versatile

Abstract

Radically unconventional: Natural products with di- and trichloromethyl groups and trifluoromethylated pharmaceuticals and agrochemicials are interesting compounds, often with intriguing properties. These types of compounds can be prepared by the direct perhaloalkylation of carbonyl compounds in which enolate reactivity and radical reactivity are merged (see scheme; Bn=benzyl).