Overexpression of angiopoietin‐2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition

Abstract

Inhibition of angiopoietin-2 is an effective and safe treatment for liver fibrosis in CCl4 -treated rats, acting mainly through the induction of vessel normalization and the attenuation of hepatic inflammatory infiltrate. Therefore, inhibition of angiopoietin-2 offers a therapeutic alternative for liver fibrosis.