High-risk human papillomavirus infections in colorectal cancer in the Syrian population and their association with Fascin, Id-1 and P-cadherin expressions: A tissue microarray study

Abstract

Background: High-risk human papillomaviruses (HPVs) can be regarded as important risk factors for colorectal carcinogenesis and metastasis. Alternatively, earlier studies have reported that Fascin, Id-1 and P-cadherin genes are important regulators of cell invasion and metastasis in several human carcinomas, including colorectal. In order to investigate the correlation between the presence of high-risk HPVs and Fascin, Id-1, and P-cadherin genes in human colorectal cancer (CRC) in the Syrian pop