Effect of Sub-Chronic Treatment with Jarsin® (Extract of St John’s Wort,<i>Hypericum perforatum</i>) at Two Dose Levels on Evening Salivary Melatonin and Cortisol Concentrations in Healthy Male Volunteers

Abstract

Salivary cortisol was enhanced in the low dose group only and melatonin was not affected by either treatment. We suggest that HP may enhance salivary cortisol via a U-shaped dose-response relationship and that this may be mediated through a 5-HT2 mechanism.