Screening for hepatitis B and vaccination of homosexual men.

Abstract

about 60%) with C4b binding protein. The concentra- tions of this protein were twice the reference values but became normal after the leg was amputated and the clinical condition stabilised (day 142). This may have been due to the reactant behaviour of this protein in the acute phase.' The concentrations of free (active) protein S calculated from total protein S and C4b binding protein with a dissociation constant of 0 7x 10-molUl for the protein S/C4b binding protein complex' agreed with those measured. This confirmed protein S deficiency as we found moderately decreased concentrations of protein S and a shift from its free form to the complexed form with C4b binding protein.