Fetal macrosomia and maternal diabetic control in pregnancy.

Abstract

clofibrate showed an increase in sex-hormone-binding capacity (119 and 7-5 x 10-8 mol/l in cases and controls respectively) and a decrease in the percentage of testosterone circulating free in the unbound state (I1 % and 1-6 % respectively), both differences being statistically significant (p <0.05).Though total testosterone was higher and oestrone and oestradiol lower in those taking clofibrate than in their controls, the differences were not significant.Comparison of men not taking medication with their matched controls showed a non-significant increase in total testosterone, oestrone, and oestradiol.When the hormone concentrations were put into a multiple Total testosterone 30 25 Percentage of free 20 77 2 testosterone nmol/l 15 10 .. 5 Sex-hormone-binding Dihydrotestosterone 15 apcity 3 10 2 Oestrone Oestradiol 0-2 0 -.21 °X n Ss ~ñ m o l / l n a- 0.0 0-0 Follicle-stimulating 50hormone Luteinising hormone hm 2 40 30u g / l 1 { 1 j ' °2 0 CasesE 7 Cnt rolsTotal Clofibrate H Other drugs H Nodrugs Hormone concentrations in cases, grouped according to current drug treatment, compared with their matched control pairs.Numbers of pairs (total=50): clofibrate, 12; other drugs, 16; no drugs, 22. (One value missing for each of % free testosterone, sex-hormone-binding capacity, oestradiol, luteinising hormone and follicle-stimulating hormone; 11 values missing for oestrone; 16 values missing for dihydrotestosterone.) Conversion: SI to traditional units-Testosterone: 1 nmol/I 28-8 ng/100 ml.Oestrone: 1 nmol/l 27 ng/ 100 ml.Dihydrotes- tosterone: 1 nmol/l129 ng/100 ml.Oestradiol: 1 nmol/l-27-2 ng/100 ml.linear regression model (to examine case-control differences while taking account of the effect of drugs and other risk factors for coronary heart disease) testosterone was a better discriminator between cases and controls (t= 1-78; p<0-10) than either oe.trone or oestradiol, but none of these hormonal differences were statistically significant.