Expression of activation‐induced, T cell–derived, and chemokine‐related cytokine/lymphotactin and its functional role in rheumatoid arthritis

Abstract

These data indicate that in RA synovium, ATAC/Lptn is mainly produced by T cells. Considering its function as a lymphocyte-specific chemoattractant, ATAC/Lptn might be a key modulator for T cell trafficking in the pathogenesis of RA. In addition, functional studies suggest that ATAC/Lptn may exert additional immunomodulatory effects in RA.