The Effects of Phenylhydrazine‐Induced Haemolysis on the Behaviour of Regenerating Marrow Stroma

Abstract

S ummary . Fragments of marrow tissue autotransplanted in a subcutaneous site, regenerate and give rise to a haemopoietic nodule surrounded by a shell of bone. The process originates from supporting stroma of implanted marrow. Phenylhydrazine‐induced acute haemolysis stimulates the growth of these implants and results in almost 100% increase in the weight of implants. This effect is probably the result of an increased demand for erythropoiesis and implies an interaction between blood‐forming cells and the marrow stroma. Phenylhydrazine‐induced chronic haemolysis, on the other hand, suppresses the growth of implants and results in a markedly lower rate of take and decreased weight of implants. This appears to be a direct effect of phenylhydrazine on cell proliferation in the regenerating implant.