Synthesis of Azomethines from α‐Oxocarboxylates, Amines and Aryl Bromides <i>via</i> One‐Pot Three‐Component Decarboxylative Coupling

Abstract

Abstract A bimetallic palladium/copper catalyst system allows the highly modular synthesis of azomethines via the decarboxylative coupling of aryl halides and α‐iminocarboxylates, generated in situ from potassium α‐oxocarboxylates and primary amines. The reaction proceeds already at 100 °C, a new record for redox‐neutral decarboxylative cross‐coupling reactions.