New ELISAs with high specificity for soluble oligomers of amyloid β‐protein detect natural Aβ oligomers in human brain but not CSF

Abstract

These new o-ELISAs with rigorously confirmed specificity can quantify oligomer burden in human and mouse brains for diagnostic and mechanistic studies and for AD biomarker development. However, our data raise the likelihood that the hydrophobicity of Aß oligomers makes them very low in number or absent in aqueous CSF.