Association of <i>Uridine Diphosphate-Glucuronosyltransferase 2B</i> Gene Variants with Serum Glucuronide Levels and Prostate Cancer Risk

Abstract

While the small sample size limits inference, our findings suggest that an association between the UGT2B17 copy number variant (CNV) and serum AAG levels in Whites, but unexpectedly not in Blacks. This novel observation suggests that genetic determinants of AAG levels in Blacks are unrelated to the UGT2B17 CNV. This study replicates the results that show an association of UGT215(D85Y) with an increased prostate cancer risk.