ω‐3 Fatty Acids Prevent Hepatic Steatosis, Independent of PPAR‐α Activity, in a Murine Model of Parenteral Nutrition–Associated Liver Disease

Abstract

PN induces TG accumulation (steatosis) in wild-type and PPAR-α null mice. In PN-fed wild-type and PPAR-α null mice given IP ω-3 FAs, reduced hepatic TG accumulation and absent steatosis are found. Prevention of steatosis by ω-3 FAs results from PPAR-α-independent pathways.