Catalytic Enantioselective 1,6‐Conjugate Addition of Grignard Reagents to Linear Dienoates

Abstract

Dual function of catalyst: Both regio- and enantioselectivity are dictated by Cu catalysis using the reversed josiphos ligand. This allows enantioselective 1,6-addition of Grignard reagents to acyclic α,β,γ,δ-unsaturated esters monosubstituted at the β and δ positions (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703702_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.