Essential Role of CD11a in CD8 ⁺ T-Cell Accumulation and Activation in Adipose Tissue

Abstract

Combined action of cytokines in obese AT induces proliferative response of CD8(+) T cells locally, which, along with increased infiltration, contributes to CD8(+) T-cell accumulation and activation in AT. CD11a plays a crucial role in AT inflammation by participating in T-cell infiltration and activation.