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Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats

Pde4 InhibitorsBiochemistryPsychiatryMedicinePsychotropic MedicationHigh-affinity RolipramDepressionPsychopharmacologyNeuropharmacologyPharmacotherapyBiological PsychiatryPharmacologyDrug DiscoveryPhosphodiesterase-4 Enzyme