Bulletin of the Chemical Society of Japan · 1974 · 108 citations · 7 references
Natural SciencesChemistryGreen ChemistryOrganometallic ChemistrySynthetic Medicinal ChemistryCarboxylic DerivativesHeterocycle SynthesisCarboxylic Acid Derivative SynthesisGrignard Reactions With Carboxylic AcidsKetones
Abstract It was found that ketones were prepared in excellent yields by the reaction of Grignard reagents with S-(2-pyridyl) thioates and their analogues or with 2-pyridyl esters. The mechanism of this reaction was also discussed. This useful method for the preparation of ketones was successfully applied to the syntheses of cis-jasmone and dihydrojasmone.
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