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THYROGLOBULIN FORMATION IN THE THYROID FOLLICLE VISUALIZED BY THE “COATED AUTOGRAPH” TECHNIQUE
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1948
Year
Nuclear MedicineIodine Deficiency DisordersThyroid DiseaseHistopathologyPathologyClassical HistologyThyroid DisordersThyroid GlandParathyroid GlandThyroid HormonePublic HealthEndocrinologyMedicineCell BiologyThyroid PhysiologyPhotographic EmulsionRadiology
The unique histological structure of the thyroid has prompted a number of attempts to relate its cytological features to the process of hormone formation. However, the theories on the subject (cf. Bargmann, 1939) have left many, so far unanswered questions. For example, do the cells secrete into the circulation or in the direction of the colloid? Does this colloid merely represent the site of storage of excess thyroid hormone or does it in fact play a role in the formation of the thyroid principle? These and similar histophysiological points have remained in doubt, presumably because of the limitations of classical histology. The use of radioactive isotopes of iodine offered a new approach to these problems. Radio-iodine may be located in sections of thyroid gland by the autographic method, which takes advantage of the action of radio-elements on a photographic emulsion. A review of the autographic results obtained to date (Gross and Leblond, 1947)