Rheumatoid arthritis association with the <i>FCRL3</i> –169C polymorphism is restricted to <i>PTPN22</i> 1858T–homozygous individuals in a Canadian population

Abstract

Our findings support an association of RA with an FCRL3 functional polymorphism and reveal that this association is stronger in the absence of PTPN22 risk genotypes. These findings support a genetic heterogeneity across RA populations, suggesting that both the FCRL3 and PTPN22 genes play roles in RA susceptibility, but in different individuals.