A Feasibility, Toxicity, and Early Response Study of Etoposide, Ifosfamide, and Vincristine for the Treatment of Children with Rhabdomyosarcoma: A Report from the Intergroup Rhabdomyosarcoma Study (IRS) IV Pilot Study

Abstract

This pilot study had toxicity and response rates comparable to the other two Intergroup Rhabdomyosarcoma Study (IRS)-IV pilot trials of vincristine-actinomycin-cyclophosphamide and vincristine-actinomycin-ifosfamide and is, therefore, being evaluated in the current IRS randomized trial. Due to the high incidence of life-threatening neutropenia and infections, the use of growth factors is now routine. Five of 11 patients who developed nephrotoxicity did so after more than eight courses of IFOS; therefore, the current randomized trial limits IFOS to a total of eight courses.