2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase

Abstract

ADVERTISEMENT RETURN TO ISSUELetterNEXT2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of FarnesyltransferaseTheresa M. Williams, Terrence M. Ciccarone, Suzanne C. MacTough, Rhonda L. Bock, Michael W. Conner, Joseph P. Davide, Kelly Hamilton, Kenneth S. Koblan, Nancy E. Kohl, Astrid M. Kral, Scott D. Mosser, Charles A. Omer, David L. Pompliano, Elaine Rands, Michael D. Schaber, Daksha Shah, Francine R. Wilson, Jackson B. Gibbs, Samuel L. Graham, George D. Hartman, Allen I. Oliff, and Robert L. SmithView Author Information Departments of Medicinal Chemistry, Cancer Research, and Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Cite this: J. Med. Chem. 1996, 39, 7, 1345–1348Publication Date (Web):March 29, 1996Publication History Received2 November 1995Published online29 March 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jm9508090https://doi.org/10.1021/jm9508090rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views759Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cells,Inhibition,Inhibitors,Monomers,Peptides and proteins Get e-Alerts