MRP8/14 Enhances Corneal Susceptibility to<i>Pseudomonas aeruginosa</i>Infection by Amplifying Inflammatory Responses

Abstract

Our study demonstrated a dual role for MRP8/14 in bacterial keratitis. Although MRP8/14 promotes bacterial clearance by enhancing ROS production, it functions more importantly as an inflammatory amplifier at the ocular surface by enhancing pro-inflammatory cytokine expression, thus contributing to the corneal susceptibility.