Further Studies on SV40-Induced Transformation in Human Renal Cell Cultures. I. Eventual Failure of Subcultivation Despite a Continuing High Rate of Cell Division.

Abstract

With a single exception human renal cells transformed by simian virus 40 exhibited eventual failure to undergo serial subcultivation. An increasing rate of aberrant nuclear division was observed concomitantly and may therefore be the immediate factor responsible for the declining growth rate.