Teratogenesis Carcinogenesis and Mutagenesis · 1983 · 20 citations · 12 references
PharmacyMicrobiologyToxicologyDrug DesignDrug DiscoveryStructure-activity RelationshipsMutagenicity AssessmentQuantitative Structure-activity RelationshipsStructure-activity Relationship AnalysisAmes Mutagenicity PredictionChromatographic BehaviorHydrogen BondingMultiple RegressionMutagen Sensitivity TestingMutagenic EffectivenessMutagenic EfficiencyMutagenic Mechanisms
The mutagenic activity of 20 5-nitroimidazoles was tested in Salmonella typhimurium TA-100 strain by means of the Ames test. A multiple regression analysis using the interaction term MR2 X Hb and the chromatographic Rm values yielded the equation: (formula see text); where C is the molar concentration (1 M X 10(-6) of each drug increasing the revertants by five times in the Ames test. The interaction term MR2 X Hb takes into account the positive effect exerted by substituents characterized by higher molar refractivity (MR2) and capable of hydrogen bonding (Hb). It was found that when the electroreduction potentials (EIc.p.) were included, the correlation was not improved.
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G.E. Adams, I. R. Flockhart, C. E. Smithen et al. · Radiation Research · 2012 · 349 citations
G.E. Adams, I. R. Flockhart, C. E. Smithen et al. · Radiation Research · 1976 · 297 citations